BOSTON — Harvard University announced Monday that it has filed suit to halt a federal freeze on more than $2.2 billion in grants after the institution said it would defy the Trump administration’s demands to limit activism on campus.

In a letter to Harvard earlier this month, the Trump administration had called for broad government and leadership reforms at the university as well as changes to its admissions policies. It also demanded that the university audit views of diversity on campus, and stop recognizing some student clubs.

Harvard President Alan Garber said the university would not bend to the government’s demands. Hours later, the government froze billions of dollars in federal funding.

“The Government has not — and cannot — identify any rational connection between antisemitism concerns and the medical, scientific, technological, and other research it has frozen that aims to save American lives, foster American success, preserve American security, and maintain America’s position as a global leader in innovation,” the university wrote in its lawsuit, filed in Boston federal court.

“Nor has the Government acknowledged the significant consequences that the indefinite freeze of billions of dollars in federal research funding will have on Harvard’s research programs, the beneficiaries of that research, and the national interest in furthering American innovation and progress,” it added.

The Trump administration did not immediately respond to an email from The Associated Press requesting comment.

In its letter dated April 11, the administration told Harvard to impose tougher discipline on protesters and to screen international students for those who are “hostile to the American values.”

It also called for broad leadership reforms at the university, changes to admissions policies and the removal of college recognition for some student clubs. The government also demanded Harvard audit its faculty and student body to ensure wide viewpoints in every department and, if necessary, diversify by admitting additional students and hiring new faculty.